Adult Clinical Trials: LUNG 

RTOG 0937

Randomized Phase II Study Comparing Prophylactic Cranial Irradiation Alone to Prophylactic Cranial Irradiation and Consolidative Extra-Cranial Irradiation for Extensive Disease Small Cell Lung Cancer (ED-SCLC)

  • Patients with SCLC without brain metastases and with 1-4 metastatic lesions.
  • Patients have to have completed 4-6 cycles of platinum-based chemotherapy and registered on study within 8 weeks of completing therapy.
  • Prior to chemotherapy, patients must have extensive stage disease with 1-4 extracranial metastatic lesions and no symptoms of CNS metastases. They must have had partial or complete response to chemotherapy in a minimum of one site of disease and no progression in any site.
  • All toxicities related to treatment must be resolved to < or equal to grade 1.
  • Patient must have limited stage disease at diagnosis and no central nervous metastases.


TREATMENT

Arm 1: Prophylactic Cranial Irradiation 2.5 Gy per fraction for a total of 25 Gy

Arm 2: Prophylactic Cranial Irradiation 2.5 Gy per fraction for a total of 25 Gy and consolidative radiation to locoregional and residual metastatic disease 45 Gy at 3 Gy per fraction